منابع مشابه
OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage
Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...
متن کاملDNA damage, repair and mutations
DNA damage, repair and mutations Harry Vrieling Introduction DNA contains the blueprint for the proper development, functioning and reproduction of organisms ranging from bacteria, low eukaryotes to vertebrates like man. It is therefore of extreme importance that both replication, i.e. the duplication of DNA, and the segregation of fully replicated DNA molecules (i.e. the chromosomes) over the ...
متن کاملDNA Damage, Repair, and Diseases
DNA is the essential carrier of genetic information in all living cells. How is the huge amount of DNA in organisms from bacteria to humans maintained and protected from the ravages of noxious agents in the environment? The chemical stability of the DNA molecule is not unusually great, DNA undergoes several types of spontaneous modifications, and it can also react with many physical and chemica...
متن کاملDNA Damage, Mutagenesis, and DNA Repair
This special issue of the Journal of Nucleic Acids is dedicated to DNA damage and two important biological consequences provoked by such damage: lesion repair and lesion-induced mutagenesis. These phenomena have attracted broad interest among a large community of scientists that cross disciplines frommathematics, physics, chemistry, and biology to clinical scientists. The importance of DNA dama...
متن کاملDNA Damage, DNA Repair and Cancer
DNA damage is a change in the basic structure of DNA that is not itself replicated when the DNA is replicated. A DNA damage can be a chemical addition or disruption to a base of DNA (creating an abnormal nucleotide or nucleotide fragment) or a break in one or both chains of the DNA strands. When DNA carrying a damaged base is replicated, an incorrect base can often be inserted opposite the site...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1981
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.30.special_69s